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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are typically characterized by a focus on the practical aspects of the research design, like the recruitment process and consent as well as adherence to the use of standard equipment.
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A pragmatic study that involves different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is vital for a pragmatic trial to be valid and reduce bias in results, is also necessary. However, too much heterogeneity could cause issues with the trial design.
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무료슬롯체험 aim to mimic real-life situations and attain maximum external validity. They are usually ordered by policymakers and practitioners in order to inform their decisions. They can be used to determine the cause-effect relationship of an intervention and its effects. They should not, however be used to replace explanation studies.
The idea of pragmatism is controversial and there are concerns about whether pragmatic trials can replace explanatory tests or if they should be an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool sought to define the characteristics of a pragmatic study that include recruitment, design and delivery of the intervention, as well as monitoring.
The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This indicates that the health science community is becoming more acquaint to the subject of pragmatism. It is important to note, however, that the majority were conducted in primary-care settings.